Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2032776..2033305 Replicon chromosome
Accession NZ_CP102953
Organism Staphylococcus aureus strain 32-T-13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW977_RS09880 Protein ID WP_000621175.1
Coordinates 2032776..2033138 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW977_RS09885 Protein ID WP_000948331.1
Coordinates 2033135..2033305 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW977_RS09860 (NW977_09860) 2029754..2030524 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW977_RS09865 (NW977_09865) 2030499..2030978 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW977_RS09870 (NW977_09870) 2030980..2031306 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW977_RS09875 (NW977_09875) 2031425..2032426 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW977_RS09880 (NW977_09880) 2032776..2033138 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW977_RS09885 (NW977_09885) 2033135..2033305 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW977_RS09890 (NW977_09890) 2033390..2034538 - 1149 WP_072496962.1 alanine racemase -
NW977_RS09895 (NW977_09895) 2034604..2034963 - 360 WP_061838820.1 holo-ACP synthase -
NW977_RS09900 (NW977_09900) 2034967..2035458 - 492 WP_072496961.1 PH domain-containing protein -
NW977_RS09905 (NW977_09905) 2035445..2037028 - 1584 WP_258414916.1 PH domain-containing protein -
NW977_RS09910 (NW977_09910) 2037021..2037500 - 480 WP_001287079.1 hypothetical protein -
NW977_RS09915 (NW977_09915) 2037709..2038269 - 561 WP_072496959.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254598 WP_000621175.1 NZ_CP102953:c2033138-2032776 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254598 WP_000948331.1 NZ_CP102953:c2033305-2033135 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References