254597

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1874506..1875282 Replicon chromosome
Accession NZ_CP102953
Organism Staphylococcus aureus strain 32-T-13

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW977_RS08965 Protein ID WP_000031108.1
Coordinates 1874506..1874658 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW977_RS08970 Protein ID WP_001251224.1
Coordinates 1874683..1875282 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW977_RS08950 (NW977_08950) 1870535..1871356 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW977_RS08955 (NW977_08955) 1871819..1873204 - 1386 WP_258413920.1 class II fumarate hydratase -
NW977_RS08960 (NW977_08960) 1873400..1873795 - 396 WP_000901023.1 hypothetical protein -
NW977_RS08965 (NW977_08965) 1874506..1874658 - 153 WP_000031108.1 SAS053 family protein Toxin
NW977_RS08970 (NW977_08970) 1874683..1875282 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW977_RS08975 (NW977_08975) 1875441..1875911 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW977_RS08980 (NW977_08980) 1875916..1877043 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
NW977_RS08985 (NW977_08985) 1877194..1877916 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW977_RS08990 (NW977_08990) 1877909..1879366 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254597 WP_000031108.1 NZ_CP102953:c1874658-1874506 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254597 WP_001251224.1 NZ_CP102953:c1875282-1874683 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References