Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2057949..2058463 Replicon chromosome
Accession NZ_CP102952
Organism Staphylococcus aureus strain 39-B-49

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW967_RS09925 Protein ID WP_000581792.1
Coordinates 2057949..2058158 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW967_RS09930 Protein ID WP_000138932.1
Coordinates 2058170..2058463 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW967_RS09905 (NW967_09905) 2053457..2054815 - 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW967_RS09910 (NW967_09910) 2054830..2055900 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW967_RS09915 (NW967_09915) 2056218..2057420 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
NW967_RS09920 (NW967_09920) 2057684..2057821 - 138 WP_000828354.1 Lmo0850 family protein -
NW967_RS09925 (NW967_09925) 2057949..2058158 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW967_RS09930 (NW967_09930) 2058170..2058463 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW967_RS09935 (NW967_09935) 2058629..2060113 + 1485 WP_000571549.1 cardiolipin synthase -
NW967_RS09940 (NW967_09940) 2060141..2060788 + 648 WP_001187630.1 HD domain-containing protein -
NW967_RS09945 (NW967_09945) 2061602..2062474 - 873 WP_000725802.1 membrane protein insertase YidC -
NW967_RS09950 (NW967_09950) 2062560..2063201 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254590 WP_000581792.1 NZ_CP102952:c2058158-2057949 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254590 WP_000138932.1 NZ_CP102952:c2058463-2058170 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References