Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2038193..2038722 Replicon chromosome
Accession NZ_CP102952
Organism Staphylococcus aureus strain 39-B-49

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW967_RS09835 Protein ID WP_000621175.1
Coordinates 2038193..2038555 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW967_RS09840 Protein ID WP_000948331.1
Coordinates 2038552..2038722 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW967_RS09815 (NW967_09815) 2035171..2035941 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
NW967_RS09820 (NW967_09820) 2035916..2036395 - 480 WP_001190829.1 anti-sigma B factor RsbW -
NW967_RS09825 (NW967_09825) 2036397..2036723 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW967_RS09830 (NW967_09830) 2036842..2037843 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW967_RS09835 (NW967_09835) 2038193..2038555 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW967_RS09840 (NW967_09840) 2038552..2038722 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW967_RS09845 (NW967_09845) 2038807..2039955 - 1149 WP_001281145.1 alanine racemase -
NW967_RS09850 (NW967_09850) 2040021..2040380 - 360 WP_000581197.1 holo-ACP synthase -
NW967_RS09855 (NW967_09855) 2040384..2040875 - 492 WP_072353916.1 PH domain-containing protein -
NW967_RS09860 (NW967_09860) 2040862..2042445 - 1584 WP_045173493.1 PH domain-containing protein -
NW967_RS09865 (NW967_09865) 2042438..2042917 - 480 WP_001287090.1 hypothetical protein -
NW967_RS09870 (NW967_09870) 2043126..2043686 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T254589 WP_000621175.1 NZ_CP102952:c2038555-2038193 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254589 WP_000948331.1 NZ_CP102952:c2038722-2038552 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References