Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1881573..1882349 Replicon chromosome
Accession NZ_CP102952
Organism Staphylococcus aureus strain 39-B-49

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW967_RS08935 Protein ID WP_000031108.1
Coordinates 1881573..1881725 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag NW967_RS08940 Protein ID WP_001251230.1
Coordinates 1881750..1882349 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW967_RS08920 (NW967_08920) 1877367..1878188 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW967_RS08925 (NW967_08925) 1878651..1880036 - 1386 WP_000116229.1 class II fumarate hydratase -
NW967_RS08930 (NW967_08930) 1880232..1880627 - 396 WP_000901023.1 hypothetical protein -
NW967_RS08935 (NW967_08935) 1881573..1881725 - 153 WP_000031108.1 SAS053 family protein Toxin
NW967_RS08940 (NW967_08940) 1881750..1882349 - 600 WP_001251230.1 hypothetical protein Antitoxin
NW967_RS08945 (NW967_08945) 1882508..1882978 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW967_RS08950 (NW967_08950) 1882983..1884110 - 1128 WP_000379988.1 tRNA epoxyqueuosine(34) reductase QueG -
NW967_RS08955 (NW967_08955) 1884261..1884983 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW967_RS08960 (NW967_08960) 1884976..1886433 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254588 WP_000031108.1 NZ_CP102952:c1881725-1881573 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22369.51 Da        Isoelectric Point: 4.9728

>AT254588 WP_001251230.1 NZ_CP102952:c1882349-1881750 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKYAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References