Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1171342..1171868 Replicon chromosome
Accession NZ_CP102950
Organism Arthrobacter sp. CJ23

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NVV90_RS05255 Protein ID WP_258440139.1
Coordinates 1171542..1171868 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NVV90_RS05250 Protein ID WP_258440138.1
Coordinates 1171342..1171545 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NVV90_RS05220 (NVV90_05220) 1166471..1167700 - 1230 WP_258440132.1 NAD(P)/FAD-dependent oxidoreductase -
NVV90_RS05225 (NVV90_05225) 1167742..1168104 - 363 WP_258440133.1 VOC family protein -
NVV90_RS05230 (NVV90_05230) 1168169..1168633 + 465 WP_258440134.1 MarR family transcriptional regulator -
NVV90_RS05235 (NVV90_05235) 1168673..1169767 - 1095 WP_258440135.1 thioredoxin domain-containing protein -
NVV90_RS05240 (NVV90_05240) 1170116..1170412 + 297 WP_258440136.1 hypothetical protein -
NVV90_RS05245 (NVV90_05245) 1170454..1171227 - 774 WP_258440137.1 alpha/beta hydrolase -
NVV90_RS05250 (NVV90_05250) 1171342..1171545 + 204 WP_258440138.1 antitoxin MazE family protein Antitoxin
NVV90_RS05255 (NVV90_05255) 1171542..1171868 + 327 WP_258440139.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NVV90_RS05260 (NVV90_05260) 1171836..1172369 - 534 WP_258440140.1 DUF2220 domain-containing protein -
NVV90_RS05265 (NVV90_05265) 1172326..1172964 - 639 WP_258440141.1 DUF3322 domain-containing protein -
NVV90_RS05270 (NVV90_05270) 1172957..1176379 - 3423 WP_258440142.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1130437..1172964 42527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-106)

Antitoxin

Antitoxin MazE-like

(5-65)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11866.79 Da        Isoelectric Point: 8.7087

>T254579 WP_258440139.1 NZ_CP102950:1171542-1171868 [Arthrobacter sp. CJ23]
VNRGELWTVSGGTYAQKPRPALIIQDDLFEASESVTLLPLTSHLTDAPLLRLTVDPGQLTGLERVSQIMIDKLTTVRRVN
LGQRIGRIDSKTMVAVEQSLIVFLGLGR

Download         Length: 327 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7929.77 Da        Isoelectric Point: 5.8508

>AT254579 WP_258440138.1 NZ_CP102950:1171342-1171545 [Arthrobacter sp. CJ23]
MSVKDRVARHRAAMRERGFRQIQVWVPDARTEEFRREARRQSLAVAASDRAGDDQDFIEQISEDWPE

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References