254569

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4459570..4460905 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag NW339_RS22045 Protein ID WP_258390124.1
Coordinates 4459958..4460905 (+) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID -
Locus tag NW339_RS22040 Protein ID WP_111986816.1
Coordinates 4459570..4459965 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS21995 (4455075) 4455075..4455560 + 486 WP_258390117.1 antirestriction protein -
NW339_RS22000 (4455576) 4455576..4456052 + 477 WP_258390118.1 RadC family protein -
NW339_RS22005 (4456115) 4456115..4456336 + 222 WP_000692323.1 DUF987 domain-containing protein -
NW339_RS22010 (4456349) 4456349..4456981 + 633 WP_258390119.1 antitoxin of toxin-antitoxin stability system -
NW339_RS22015 (4457031) 4457031..4457399 + 369 WP_258390120.1 type IV toxin-antitoxin system YeeU family antitoxin -
NW339_RS22020 (4457488) 4457488..4457865 + 378 WP_258390121.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA -
NW339_RS22025 (4457862) 4457862..4458350 + 489 WP_258390122.1 DUF5983 family protein -
NW339_RS22030 (4458362) 4458362..4458559 + 198 WP_000839249.1 DUF957 domain-containing protein -
NW339_RS22035 (4458656) 4458656..4459501 + 846 WP_258390123.1 DUF4942 domain-containing protein -
NW339_RS22040 (4459570) 4459570..4459965 + 396 WP_111986816.1 DUF6088 family protein Antitoxin
NW339_RS22045 (4459958) 4459958..4460905 + 948 WP_258390124.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NW339_RS22050 (4461309) 4461309..4461468 + 160 Protein_4323 integrase -
NW339_RS22055 (4461728) 4461728..4463265 + 1538 Protein_4324 lysine decarboxylation/transport transcriptional activator CadC -
NW339_RS22060 (4463631) 4463631..4464965 + 1335 WP_000092909.1 cadaverine/lysine antiporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-302)

Antitoxin

Protein of unknown function DUF6088

(10-129)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 36246.58 Da        Isoelectric Point: 5.7165

>T254569 WP_258390124.1 NZ_CP102947:4459958-4460905 [Escherichia coli]
MPELTSLFPDVANALDIESVAIVEKDYFVVNLLKLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDRRRKVRKEIVQIITDVLHNSDIFSLDNENARITRDEYRYNEIPVRYPQTFAQAPCLRPFIKLELMETTLLEHPESR
DIYSLVTELTGNGTPVTAFPCATILSTQAEKLISMMRRTAILLRNPEQQDDESLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQHPQFCNSPVDELKKGLDALRDDPVHKLRFQRFVKPMVFGNTQIDWEEAYSCFRQTALSVLTN

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14610.99 Da        Isoelectric Point: 10.9907

>AT254569 WP_111986816.1 NZ_CP102947:4459570-4459965 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGKALRTLVNEGKLMKVGYGVYTKARRNVITGKIMPAAPGGSAAVITE
ALDRLNIRYSLIGATECYNKGQSTQIPVSPEFKTPPRFKRVLVVGKSKINA

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References