254568

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4457031..4457865 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NW339_RS22020 Protein ID WP_258390121.1
Coordinates 4457488..4457865 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NW339_RS22015 Protein ID WP_258390120.1
Coordinates 4457031..4457399 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS21975 (4452158) 4452158..4453042 + 885 WP_258390115.1 YfjP family GTPase -
NW339_RS21980 (4453161) 4453161..4453838 + 678 WP_001097364.1 hypothetical protein -
NW339_RS21985 (4453844) 4453844..4454077 + 234 WP_258390116.1 DUF905 domain-containing protein -
NW339_RS21990 (4454167) 4454167..4454984 + 818 Protein_4311 DUF945 domain-containing protein -
NW339_RS21995 (4455075) 4455075..4455560 + 486 WP_258390117.1 antirestriction protein -
NW339_RS22000 (4455576) 4455576..4456052 + 477 WP_258390118.1 RadC family protein -
NW339_RS22005 (4456115) 4456115..4456336 + 222 WP_000692323.1 DUF987 domain-containing protein -
NW339_RS22010 (4456349) 4456349..4456981 + 633 WP_258390119.1 antitoxin of toxin-antitoxin stability system -
NW339_RS22015 (4457031) 4457031..4457399 + 369 WP_258390120.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NW339_RS22020 (4457488) 4457488..4457865 + 378 WP_258390121.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
NW339_RS22025 (4457862) 4457862..4458350 + 489 WP_258390122.1 DUF5983 family protein -
NW339_RS22030 (4458362) 4458362..4458559 + 198 WP_000839249.1 DUF957 domain-containing protein -
NW339_RS22035 (4458656) 4458656..4459501 + 846 WP_258390123.1 DUF4942 domain-containing protein -
NW339_RS22040 (4459570) 4459570..4459965 + 396 WP_111986816.1 DUF6088 family protein -
NW339_RS22045 (4459958) 4459958..4460905 + 948 WP_258390124.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
NW339_RS22050 (4461309) 4461309..4461468 + 160 Protein_4323 integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14003.07 Da        Isoelectric Point: 7.2142

>T254568 WP_258390121.1 NZ_CP102947:4457488-4457865 [Escherichia coli]
MKTLPVLPGQVASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTCSQLINNIDILRARRATGLMTRDNYRTVNNITLGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13795.62 Da        Isoelectric Point: 6.0666

>AT254568 WP_258390120.1 NZ_CP102947:4457031-4457399 [Escherichia coli]
VSDKLHETTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLELMLTSG
ELNPHRQNTVTLYARGLTCEADTLGSCGYIYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References