Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4234067..4234902 | Replicon | chromosome |
| Accession | NZ_CP102947 | ||
| Organism | Escherichia coli strain SCAID WND1-2022 (119) | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0J2AEA6 |
| Locus tag | NW339_RS20825 | Protein ID | WP_000854759.1 |
| Coordinates | 4234067..4234444 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | NW339_RS20830 | Protein ID | WP_001295723.1 |
| Coordinates | 4234534..4234902 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NW339_RS20800 (4230178) | 4230178..4231800 | - | 1623 | WP_001295726.1 | Alw26I/Eco31I/Esp3I family type II restriction adenine-specific DNA-methyltransferase | - |
| NW339_RS20805 (4232591) | 4232591..4232767 | - | 177 | Protein_4079 | helix-turn-helix domain-containing protein | - |
| NW339_RS20810 (4233134) | 4233134..4233283 | - | 150 | Protein_4080 | hypothetical protein | - |
| NW339_RS20815 (4233389) | 4233389..4233565 | - | 177 | WP_000839286.1 | DUF957 domain-containing protein | - |
| NW339_RS20820 (4233582) | 4233582..4234070 | - | 489 | WP_000761690.1 | DUF5983 family protein | - |
| NW339_RS20825 (4234067) | 4234067..4234444 | - | 378 | WP_000854759.1 | TA system toxin CbtA family protein | Toxin |
| NW339_RS20830 (4234534) | 4234534..4234902 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NW339_RS20835 (4235065) | 4235065..4235286 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| NW339_RS20840 (4235349) | 4235349..4235825 | - | 477 | WP_001186775.1 | RadC family protein | - |
| NW339_RS20845 (4235841) | 4235841..4236314 | - | 474 | WP_001350782.1 | antirestriction protein | - |
| NW339_RS20850 (4236760) | 4236760..4237506 | - | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| NW339_RS20855 (4237521) | 4237521..4239062 | - | 1542 | WP_001298859.1 | IS21-like element ISEc12 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14144.26 Da Isoelectric Point: 7.3249
>T254566 WP_000854759.1 NZ_CP102947:c4234444-4234067 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT254566 WP_001295723.1 NZ_CP102947:c4234902-4234534 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0J2AEA6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |