254564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4062683..4063203 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name ccdB Uniprot ID A0A061KX66
Locus tag NW339_RS20005 Protein ID WP_001160964.1
Coordinates 4062683..4062967 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag NW339_RS20010 Protein ID WP_000125566.1
Coordinates 4062970..4063203 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS19980 (4058328) 4058328..4059614 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
NW339_RS19985 (4059614) 4059614..4060603 + 990 WP_000241227.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
NW339_RS19990 (4060600) 4060600..4061421 + 822 WP_001065365.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NW339_RS19995 (4061424) 4061424..4061801 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
NW339_RS20000 (4061808) 4061808..4062656 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
NW339_RS20005 (4062683) 4062683..4062967 - 285 WP_001160964.1 CcdB family protein Toxin
NW339_RS20010 (4062970) 4062970..4063203 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NW339_RS20015 (4063289) 4063289..4063768 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
NW339_RS20020 (4063960) 4063960..4065822 - 1863 WP_000377106.1 glutathione-regulated potassium-efflux system protein KefC -
NW339_RS20025 (4065815) 4065815..4066345 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
NW339_RS20030 (4066453) 4066453..4067784 - 1332 WP_001183209.1 MFS transporter -
NW339_RS20035 (4067843) 4067843..4068130 - 288 WP_000203744.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-93)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10692.54 Da        Isoelectric Point: 10.3030

>T254564 WP_001160964.1 NZ_CP102947:c4062967-4062683 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLIDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIK

Download         Length: 285 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT254564 WP_000125566.1 NZ_CP102947:c4063203-4062970 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KX66

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References