254549

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 290096..290896 Replicon chromosome
Accession NZ_CP102947
Organism Escherichia coli strain SCAID WND1-2022 (119)

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag NW339_RS01350 Protein ID WP_000342452.1
Coordinates 290369..290896 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag NW339_RS01345 Protein ID WP_001277107.1
Coordinates 290096..290362 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW339_RS01325 (285755) 285755..286423 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
NW339_RS01330 (286416) 286416..287474 + 1059 WP_001042013.1 permease-like cell division protein FtsX -
NW339_RS01335 (287719) 287719..288573 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NW339_RS01340 (288844) 288844..289947 + 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NW339_RS01345 (290096) 290096..290362 + 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NW339_RS01350 (290369) 290369..290896 + 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NW339_RS01355 (290893) 290893..291276 - 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
NW339_RS01360 (291699) 291699..292808 + 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NW339_RS01365 (292856) 292856..293782 + 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NW339_RS01370 (293779) 293779..295056 + 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
NW339_RS01375 (295053) 295053..295820 + 768 WP_000082099.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T254549 WP_000342452.1 NZ_CP102947:290369-290896 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT254549 WP_001277107.1 NZ_CP102947:290096-290362 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References