254547

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5245901..5246541 Replicon chromosome
Accession NZ_CP102946
Organism Pseudomonas aeruginosa strain SCAID WND1-2022 (148)

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NW341_RS24380 Protein ID WP_003105740.1
Coordinates 5245901..5246311 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q6X2S2
Locus tag NW341_RS24385 Protein ID WP_003158175.1
Coordinates 5246311..5246541 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW341_RS24340 (NW341_24340) 5241770..5241940 + 171 WP_003159716.1 hypothetical protein -
NW341_RS24345 (NW341_24345) 5242096..5242824 + 729 WP_003105754.1 TIGR03761 family integrating conjugative element protein -
NW341_RS24350 (NW341_24350) 5242830..5243378 + 549 WP_003105753.1 DUF3158 family protein -
NW341_RS24355 (NW341_24355) 5243425..5244264 + 840 WP_003105750.1 Rha family transcriptional regulator -
NW341_RS24360 (NW341_24360) 5244294..5244782 + 489 WP_003105748.1 single-stranded DNA-binding protein -
NW341_RS24365 (NW341_24365) 5244938..5245135 + 198 WP_003109353.1 CrpP family ICE-associated protein -
NW341_RS24370 (NW341_24370) 5245201..5245419 - 219 WP_003105747.1 hypothetical protein -
NW341_RS24375 (NW341_24375) 5245619..5245879 - 261 WP_003105742.1 hypothetical protein -
NW341_RS24380 (NW341_24380) 5245901..5246311 - 411 WP_003105740.1 tRNA(fMet)-specific endonuclease VapC Toxin
NW341_RS24385 (NW341_24385) 5246311..5246541 - 231 WP_003158175.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NW341_RS24390 (NW341_24390) 5246797..5248716 + 1920 WP_004352838.1 type I DNA topoisomerase -
NW341_RS24395 (NW341_24395) 5249024..5249233 + 210 WP_003105733.1 cold-shock protein -
NW341_RS24400 (NW341_24400) 5249454..5251343 + 1890 WP_003105732.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5226330..5329158 102828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-35)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15450.81 Da        Isoelectric Point: 7.3233

>T254547 WP_003105740.1 NZ_CP102946:c5246311-5245901 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVVPIV

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8480.41 Da        Isoelectric Point: 4.2821

>AT254547 WP_003158175.1 NZ_CP102946:c5246541-5246311 [Pseudomonas aeruginosa]
MEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVVVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q6X2S2

References