Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3636619..3637840 Replicon chromosome
Accession NZ_CP102946
Organism Pseudomonas aeruginosa strain SCAID WND1-2022 (148)

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag NW341_RS16755 Protein ID WP_003102740.1
Coordinates 3637262..3637840 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NW341_RS16750 Protein ID WP_003088112.1
Coordinates 3636619..3637173 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW341_RS16725 (NW341_16725) 3632187..3632738 + 552 WP_004343115.1 XRE family transcriptional regulator -
NW341_RS16730 (NW341_16730) 3632735..3633133 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NW341_RS16735 (NW341_16735) 3633146..3633469 - 324 WP_003102734.1 multidrug efflux SMR transporter -
NW341_RS16740 (NW341_16740) 3633800..3634261 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
NW341_RS16745 (NW341_16745) 3634266..3636461 + 2196 WP_016263578.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NW341_RS16750 (NW341_16750) 3636619..3637173 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NW341_RS16755 (NW341_16755) 3637262..3637840 + 579 WP_003102740.1 HD domain-containing protein Toxin
NW341_RS16760 (NW341_16760) 3637949..3639136 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
NW341_RS16765 (NW341_16765) 3639126..3641297 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
NW341_RS16770 (NW341_16770) 3641287..3642564 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T254544 WP_003102740.1 NZ_CP102946:3637262-3637840 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT254544 WP_003088112.1 NZ_CP102946:3636619-3637173 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References