254543

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1868332..1869840 Replicon chromosome
Accession NZ_CP102946
Organism Pseudomonas aeruginosa strain SCAID WND1-2022 (148)

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag NW341_RS08730 Protein ID WP_003119682.1
Coordinates 1868332..1868919 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag NW341_RS08735 Protein ID WP_003115566.1
Coordinates 1868986..1869840 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW341_RS08725 (NW341_08725) 1864587..1868066 - 3480 WP_033877375.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
NW341_RS08730 (NW341_08730) 1868332..1868919 + 588 WP_003119682.1 GNAT family protein Toxin
NW341_RS08735 (NW341_08735) 1868986..1869840 + 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
NW341_RS08740 (NW341_08740) 1869937..1872102 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
NW341_RS08745 (NW341_08745) 1872277..1874151 + 1875 WP_003117607.1 MFS transporter -
NW341_RS08750 (NW341_08750) 1874212..1874421 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T254543 WP_003119682.1 NZ_CP102946:1868332-1868919 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT254543 WP_003115566.1 NZ_CP102946:1868986-1869840 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References