254542

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141537..142042 Replicon chromosome
Accession NZ_CP102946
Organism Pseudomonas aeruginosa strain SCAID WND1-2022 (148)

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag NW341_RS00645 Protein ID WP_003121619.1
Coordinates 141537..141818 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag NW341_RS00650 Protein ID WP_003112628.1
Coordinates 141815..142042 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW341_RS00620 (NW341_00620) 136788..138137 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
NW341_RS00625 (NW341_00625) 138186..138872 + 687 WP_033877486.1 FadR/GntR family transcriptional regulator -
NW341_RS00630 (NW341_00630) 138973..139707 + 735 WP_004346926.1 GntR family transcriptional regulator -
NW341_RS00635 (NW341_00635) 139887..140297 + 411 WP_003101225.1 aegerolysin family protein -
NW341_RS00640 (NW341_00640) 140329..141237 - 909 WP_003083769.1 LysR family transcriptional regulator -
NW341_RS00645 (NW341_00645) 141537..141818 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
NW341_RS00650 (NW341_00650) 141815..142042 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
NW341_RS00655 (NW341_00655) 142218..142838 - 621 WP_023088714.1 hypothetical protein -
NW341_RS00660 (NW341_00660) 142939..143439 + 501 WP_003101228.1 LEA type 2 family protein -
NW341_RS00665 (NW341_00665) 143512..143853 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
NW341_RS00670 (NW341_00670) 143935..145362 - 1428 WP_003083784.1 GABA permease -
NW341_RS00675 (NW341_00675) 145531..147024 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T254542 WP_003121619.1 NZ_CP102946:c141818-141537 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT254542 WP_003112628.1 NZ_CP102946:c142042-141815 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB Q9I707

References