Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2494605..2495128 Replicon chromosome
Accession NZ_CP102945
Organism Staphylococcus aureus strain SCAID OTT1-2022 (150)

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag NW338_RS12535 Protein ID WP_000074049.1
Coordinates 2494605..2494871 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag NW338_RS12540 Protein ID WP_000587616.1
Coordinates 2494871..2495128 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW338_RS12515 (2489912) 2489912..2491099 - 1188 WP_000026189.1 MFS transporter -
NW338_RS12520 (2491495) 2491495..2492271 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
NW338_RS12525 (2492264) 2492264..2492926 - 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
NW338_RS12530 (2493174) 2493174..2494250 - 1077 WP_001076673.1 M42 family metallopeptidase -
NW338_RS12535 (2494605) 2494605..2494871 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
NW338_RS12540 (2494871) 2494871..2495128 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW338_RS12545 (2495487) 2495487..2495942 + 456 WP_000732076.1 DUF1307 domain-containing protein -
NW338_RS12550 (2496110) 2496110..2497687 - 1578 WP_084977654.1 FMN-binding glutamate synthase family protein -
NW338_RS12555 (2497882) 2497882..2498631 + 750 WP_000072458.1 CPBP family lipoprotein N-acylation protein LnsB -
NW338_RS12560 (2498855) 2498855..2500048 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T254541 WP_000074049.1 NZ_CP102945:c2494871-2494605 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT254541 WP_000587616.1 NZ_CP102945:c2495128-2494871 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References