Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2125468..2125982 Replicon chromosome
Accession NZ_CP102945
Organism Staphylococcus aureus strain SCAID OTT1-2022 (150)

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag NW338_RS10615 Protein ID WP_000581792.1
Coordinates 2125468..2125677 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag NW338_RS10620 Protein ID WP_000138932.1
Coordinates 2125689..2125982 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW338_RS10595 (2120976) 2120976..2122334 - 1359 WP_000611459.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
NW338_RS10600 (2122349) 2122349..2123419 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
NW338_RS10605 (2123737) 2123737..2124939 + 1203 WP_001109936.1 FtsW/RodA/SpoVE family cell cycle protein -
NW338_RS10610 (2125203) 2125203..2125340 - 138 WP_000828354.1 Lmo0850 family protein -
NW338_RS10615 (2125468) 2125468..2125677 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
NW338_RS10620 (2125689) 2125689..2125982 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
NW338_RS10625 (2126148) 2126148..2127632 + 1485 WP_000571549.1 cardiolipin synthase -
NW338_RS10630 (2127660) 2127660..2128307 + 648 WP_001187630.1 HD domain-containing protein -
NW338_RS10635 (2128773) 2128773..2129645 - 873 WP_000725802.1 membrane protein insertase YidC -
NW338_RS10640 (2129731) 2129731..2130372 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T254537 WP_000581792.1 NZ_CP102945:c2125677-2125468 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT254537 WP_000138932.1 NZ_CP102945:c2125982-2125689 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References