Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2105710..2106239 Replicon chromosome
Accession NZ_CP102945
Organism Staphylococcus aureus strain SCAID OTT1-2022 (150)

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NW338_RS10525 Protein ID WP_000621177.1
Coordinates 2105710..2106072 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag NW338_RS10530 Protein ID WP_000948331.1
Coordinates 2106069..2106239 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW338_RS10505 (2102688) 2102688..2103458 - 771 WP_258389928.1 RNA polymerase sigma factor SigB -
NW338_RS10510 (2103433) 2103433..2103912 - 480 WP_258389929.1 anti-sigma B factor RsbW -
NW338_RS10515 (2103914) 2103914..2104240 - 327 WP_001052491.1 anti-sigma factor antagonist -
NW338_RS10520 (2104359) 2104359..2105360 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
NW338_RS10525 (2105710) 2105710..2106072 - 363 WP_000621177.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NW338_RS10530 (2106069) 2106069..2106239 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
NW338_RS10535 (2106324) 2106324..2107472 - 1149 WP_001281147.1 alanine racemase -
NW338_RS10540 (2107538) 2107538..2107897 - 360 WP_000581202.1 holo-ACP synthase -
NW338_RS10545 (2107901) 2107901..2108392 - 492 WP_001205910.1 PH domain-containing protein -
NW338_RS10550 (2108379) 2108379..2109962 - 1584 WP_001294627.1 PH domain-containing protein -
NW338_RS10555 (2109955) 2109955..2110434 - 480 WP_001287078.1 hypothetical protein -
NW338_RS10560 (2110643) 2110643..2111203 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13471.72 Da        Isoelectric Point: 10.1654

>T254536 WP_000621177.1 NZ_CP102945:c2106072-2105710 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNTVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT254536 WP_000948331.1 NZ_CP102945:c2106239-2106069 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References