Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1895467..1896243 Replicon chromosome
Accession NZ_CP102945
Organism Staphylococcus aureus strain SCAID OTT1-2022 (150)

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag NW338_RS09215 Protein ID WP_000031108.1
Coordinates 1895467..1895619 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag NW338_RS09220 Protein ID WP_001251224.1
Coordinates 1895644..1896243 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW338_RS09200 (1891658) 1891658..1892479 + 822 WP_000669376.1 RluA family pseudouridine synthase -
NW338_RS09205 (1892943) 1892943..1894328 - 1386 WP_000116234.1 class II fumarate hydratase -
NW338_RS09210 (1894524) 1894524..1894919 - 396 WP_000901023.1 hypothetical protein -
NW338_RS09215 (1895467) 1895467..1895619 - 153 WP_000031108.1 SAS053 family protein Toxin
NW338_RS09220 (1895644) 1895644..1896243 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
NW338_RS09225 (1896402) 1896402..1896872 - 471 WP_000181392.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
NW338_RS09230 (1896877) 1896877..1898004 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
NW338_RS09235 (1898155) 1898155..1898877 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
NW338_RS09240 (1898870) 1898870..1900327 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T254531 WP_000031108.1 NZ_CP102945:c1895619-1895467 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT254531 WP_001251224.1 NZ_CP102945:c1896243-1895644 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References