Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5548806..5549392 Replicon chromosome
Accession NZ_CP102944
Organism Pseudomonas aeruginosa strain SCAID TCT1-2022 (325)

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag NW342_RS26050 Protein ID WP_003120987.1
Coordinates 5549093..5549392 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NW342_RS26045 Protein ID WP_003448662.1
Coordinates 5548806..5549096 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW342_RS26030 (NW342_26030) 5544381..5546276 + 1896 WP_202551604.1 hypothetical protein -
NW342_RS26035 (NW342_26035) 5546273..5548249 + 1977 WP_022579622.1 DEAD/DEAH box helicase -
NW342_RS26040 (NW342_26040) 5548388..5548723 + 336 WP_022579623.1 hypothetical protein -
NW342_RS26045 (NW342_26045) 5548806..5549096 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
NW342_RS26050 (NW342_26050) 5549093..5549392 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW342_RS26055 (NW342_26055) 5549594..5550718 + 1125 WP_023093672.1 TcpQ domain-containing protein -
NW342_RS26060 (NW342_26060) 5550718..5552427 + 1710 WP_023093673.1 PilN family type IVB pilus formation outer membrane protein -
NW342_RS26065 (NW342_26065) 5552431..5553756 + 1326 WP_022579625.1 type 4b pilus protein PilO2 -
NW342_RS26070 (NW342_26070) 5553746..5554279 + 534 WP_004352829.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5518957..5607929 88972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T254528 WP_003120987.1 NZ_CP102944:c5549392-5549093 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT254528 WP_003448662.1 NZ_CP102944:c5549096-5548806 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References