254527

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5146645..5147253 Replicon chromosome
Accession NZ_CP102944
Organism Pseudomonas aeruginosa strain SCAID TCT1-2022 (325)

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag NW342_RS24185 Protein ID WP_019486378.1
Coordinates 5146645..5146992 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag NW342_RS24190 Protein ID WP_003114155.1
Coordinates 5147002..5147253 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW342_RS24155 (NW342_24155) 5142004..5142276 + 273 WP_074241374.1 cysteine-rich CWC family protein -
NW342_RS24160 (NW342_24160) 5142276..5142968 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
NW342_RS24165 (NW342_24165) 5143104..5144147 + 1044 WP_003134392.1 L,D-transpeptidase -
NW342_RS24170 (NW342_24170) 5144227..5144964 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
NW342_RS24175 (NW342_24175) 5145416..5146318 + 903 WP_003085447.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
NW342_RS24185 (NW342_24185) 5146645..5146992 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW342_RS24190 (NW342_24190) 5147002..5147253 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW342_RS24195 (NW342_24195) 5147467..5148450 - 984 WP_033990852.1 tyrosine-type recombinase/integrase -
NW342_RS24200 (NW342_24200) 5148450..5149742 - 1293 WP_033990854.1 hypothetical protein -
NW342_RS24205 (NW342_24205) 5149972..5151246 - 1275 WP_033990855.1 zonular occludens toxin family protein -
NW342_RS24210 (NW342_24210) 5151250..5151606 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5146645..5172349 25704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T254527 WP_019486378.1 NZ_CP102944:c5146992-5146645 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT254527 WP_003114155.1 NZ_CP102944:c5147253-5147002 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References