Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4671270..4672528 Replicon chromosome
Accession NZ_CP102944
Organism Pseudomonas aeruginosa strain SCAID TCT1-2022 (325)

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag NW342_RS21760 Protein ID WP_003086331.1
Coordinates 4671270..4672025 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NW342_RS21765 Protein ID WP_003086329.1
Coordinates 4672160..4672528 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW342_RS21750 (NW342_21750) 4666441..4668984 + 2544 WP_031686396.1 acyl-homoserine-lactone acylase QuiP -
NW342_RS21755 (NW342_21755) 4669139..4670500 - 1362 WP_073647918.1 DNA recombination protein RmuC -
NW342_RS21760 (NW342_21760) 4671270..4672025 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
NW342_RS21765 (NW342_21765) 4672160..4672528 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NW342_RS21770 (NW342_21770) 4672601..4673887 - 1287 WP_031756378.1 FAD-binding oxidoreductase -
NW342_RS21775 (NW342_21775) 4673943..4675532 - 1590 WP_074241293.1 aldehyde dehydrogenase family protein -
NW342_RS21780 (NW342_21780) 4675611..4676087 + 477 WP_003086322.1 hypothetical protein -
NW342_RS21785 (NW342_21785) 4676090..4676365 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T254526 WP_003086331.1 NZ_CP102944:c4672025-4671270 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT254526 WP_003086329.1 NZ_CP102944:c4672528-4672160 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References