Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3692736..3693956 Replicon chromosome
Accession NZ_CP102944
Organism Pseudomonas aeruginosa strain SCAID TCT1-2022 (325)

Toxin (Protein)


Gene name vapC Uniprot ID A0A3S3XIW1
Locus tag NW342_RS17100 Protein ID WP_033991668.1
Coordinates 3693378..3693956 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NW342_RS17095 Protein ID WP_003088112.1
Coordinates 3692736..3693290 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW342_RS17070 (NW342_17070) 3688304..3688855 + 552 WP_003132721.1 XRE family transcriptional regulator -
NW342_RS17075 (NW342_17075) 3688852..3689250 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
NW342_RS17080 (NW342_17080) 3689263..3689586 - 324 WP_003102734.1 multidrug efflux SMR transporter -
NW342_RS17085 (NW342_17085) 3689917..3690378 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
NW342_RS17090 (NW342_17090) 3690383..3692578 + 2196 WP_003139882.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NW342_RS17095 (NW342_17095) 3692736..3693290 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NW342_RS17100 (NW342_17100) 3693378..3693956 + 579 WP_033991668.1 HD domain-containing protein Toxin
NW342_RS17105 (NW342_17105) 3694066..3695253 - 1188 WP_003132729.1 HlyD family efflux transporter periplasmic adaptor subunit -
NW342_RS17110 (NW342_17110) 3695243..3697414 - 2172 WP_023106617.1 type I secretion system permease/ATPase -
NW342_RS17115 (NW342_17115) 3697404..3698681 - 1278 WP_003088104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21947.77 Da        Isoelectric Point: 5.3655

>T254525 WP_033991668.1 NZ_CP102944:3693378-3693956 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLFQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT254525 WP_003088112.1 NZ_CP102944:3692736-3693290 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3XIW1

Antitoxin

Source ID Structure

References