Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1964414..1965922 Replicon chromosome
Accession NZ_CP102944
Organism Pseudomonas aeruginosa strain SCAID TCT1-2022 (325)

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NW342_RS09165 Protein ID WP_074198311.1
Coordinates 1964414..1965001 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag NW342_RS09170 Protein ID WP_003091607.1
Coordinates 1965068..1965922 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW342_RS09160 (NW342_09160) 1960669..1964148 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
NW342_RS09165 (NW342_09165) 1964414..1965001 + 588 WP_074198311.1 GNAT family protein Toxin
NW342_RS09170 (NW342_09170) 1965068..1965922 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
NW342_RS09175 (NW342_09175) 1966019..1968184 + 2166 WP_033990934.1 TonB-dependent receptor family protein -
NW342_RS09180 (NW342_09180) 1968359..1970233 + 1875 WP_003117607.1 MFS transporter -
NW342_RS09185 (NW342_09185) 1970294..1970503 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21931.26 Da        Isoelectric Point: 9.8676

>T254524 WP_074198311.1 NZ_CP102944:1964414-1965001 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKATLEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT254524 WP_003091607.1 NZ_CP102944:1965068-1965922 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References