Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
Location | 251131..251636 | Replicon | chromosome |
Accession | NZ_CP102944 | ||
Organism | Pseudomonas aeruginosa strain SCAID TCT1-2022 (325) |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A3S3VVC5 |
Locus tag | NW342_RS01225 | Protein ID | WP_031640969.1 |
Coordinates | 251131..251412 (-) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A1C7BDS9 |
Locus tag | NW342_RS01230 | Protein ID | WP_003083775.1 |
Coordinates | 251409..251636 (-) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NW342_RS01200 (NW342_01200) | 246382..247731 | + | 1350 | WP_003137006.1 | C4-dicarboxylate transporter DctA | - |
NW342_RS01205 (NW342_01205) | 247780..248466 | + | 687 | WP_003083762.1 | FadR/GntR family transcriptional regulator | - |
NW342_RS01210 (NW342_01210) | 248567..249301 | + | 735 | WP_003128333.1 | GntR family transcriptional regulator | - |
NW342_RS01215 (NW342_01215) | 249481..249891 | + | 411 | WP_003110659.1 | aegerolysin family protein | - |
NW342_RS01220 (NW342_01220) | 249923..250831 | - | 909 | WP_033990895.1 | LysR family transcriptional regulator | - |
NW342_RS01225 (NW342_01225) | 251131..251412 | - | 282 | WP_031640969.1 | type II toxin-antitoxin system toxin ParE | Toxin |
NW342_RS01230 (NW342_01230) | 251409..251636 | - | 228 | WP_003083775.1 | CopG family ribbon-helix-helix protein | Antitoxin |
NW342_RS01235 (NW342_01235) | 251812..252432 | - | 621 | WP_003101226.1 | hypothetical protein | - |
NW342_RS01240 (NW342_01240) | 252533..253033 | + | 501 | WP_003101228.1 | LEA type 2 family protein | - |
NW342_RS01245 (NW342_01245) | 253105..253446 | + | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
NW342_RS01250 (NW342_01250) | 253528..254955 | - | 1428 | WP_003083784.1 | GABA permease | - |
NW342_RS01255 (NW342_01255) | 255124..256617 | - | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10475.19 Da Isoelectric Point: 10.0435
>T254523 WP_031640969.1 NZ_CP102944:c251412-251131 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S3VVC5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1C7BDS9 |