254523

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 251131..251636 Replicon chromosome
Accession NZ_CP102944
Organism Pseudomonas aeruginosa strain SCAID TCT1-2022 (325)

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag NW342_RS01225 Protein ID WP_031640969.1
Coordinates 251131..251412 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag NW342_RS01230 Protein ID WP_003083775.1
Coordinates 251409..251636 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW342_RS01200 (NW342_01200) 246382..247731 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
NW342_RS01205 (NW342_01205) 247780..248466 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
NW342_RS01210 (NW342_01210) 248567..249301 + 735 WP_003128333.1 GntR family transcriptional regulator -
NW342_RS01215 (NW342_01215) 249481..249891 + 411 WP_003110659.1 aegerolysin family protein -
NW342_RS01220 (NW342_01220) 249923..250831 - 909 WP_033990895.1 LysR family transcriptional regulator -
NW342_RS01225 (NW342_01225) 251131..251412 - 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
NW342_RS01230 (NW342_01230) 251409..251636 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
NW342_RS01235 (NW342_01235) 251812..252432 - 621 WP_003101226.1 hypothetical protein -
NW342_RS01240 (NW342_01240) 252533..253033 + 501 WP_003101228.1 LEA type 2 family protein -
NW342_RS01245 (NW342_01245) 253105..253446 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
NW342_RS01250 (NW342_01250) 253528..254955 - 1428 WP_003083784.1 GABA permease -
NW342_RS01255 (NW342_01255) 255124..256617 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T254523 WP_031640969.1 NZ_CP102944:c251412-251131 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp


Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT254523 WP_003083775.1 NZ_CP102944:c251636-251409 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References