Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 265359..266007 Replicon chromosome
Accession NZ_CP102942
Organism Stenotrophomonas maltophilia strain SCAID WND1-2022 (370)

Toxin (Protein)


Gene name PumA Uniprot ID B2FJ07
Locus tag NW343_RS01185 Protein ID WP_012478870.1
Coordinates 265359..265646 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NW343_RS01190 Protein ID WP_012478871.1
Coordinates 265705..266007 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW343_RS01155 (NW343_01155) 260619..261587 + 969 WP_012478821.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
NW343_RS01160 (NW343_01160) 261584..262315 + 732 WP_005407698.1 type III pantothenate kinase -
NW343_RS01165 (NW343_01165) 262325..263173 + 849 WP_049417982.1 SPOR domain-containing protein -
NW343_RS01175 (NW343_01175) 263374..264498 - 1125 WP_012478868.1 hypothetical protein -
NW343_RS01180 (NW343_01180) 264526..265125 - 600 WP_012478869.1 hypothetical protein -
NW343_RS01185 (NW343_01185) 265359..265646 + 288 WP_012478870.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW343_RS01190 (NW343_01190) 265705..266007 + 303 WP_012478871.1 putative addiction module antidote protein Antitoxin
NW343_RS01195 (NW343_01195) 266065..266388 - 324 WP_012478872.1 hypothetical protein -
NW343_RS01200 (NW343_01200) 266468..266875 - 408 WP_044569408.1 hypothetical protein -
NW343_RS01205 (NW343_01205) 267469..268239 + 771 WP_012478874.1 DUF3011 domain-containing protein -
NW343_RS01210 (NW343_01210) 268236..269243 + 1008 WP_232092433.1 ankyrin repeat domain-containing protein -
NW343_RS01215 (NW343_01215) 269348..270268 + 921 WP_005407709.1 arginase -
NW343_RS01220 (NW343_01220) 270429..270566 + 138 WP_005407710.1 entericidin A/B family lipoprotein -
NW343_RS01225 (NW343_01225) 270774..270995 + 222 WP_004153772.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10802.42 Da        Isoelectric Point: 10.8940

>T254521 WP_012478870.1 NZ_CP102942:265359-265646 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLGDGISELRIDAGPGYRLYYTQRGRQLLILLVGGDKSS
QQRDIEKAREIARAL

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10738.32 Da        Isoelectric Point: 8.0343

>AT254521 WP_012478871.1 NZ_CP102942:265705-266007 [Stenotrophomonas maltophilia]
MATKKKVELKSFDVAEHLRTPEEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FATILKVTRALGVRLHASAV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854E218

Antitoxin

Source ID Structure

References