Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 107318..108901 Replicon chromosome
Accession NZ_CP102942
Organism Stenotrophomonas maltophilia strain SCAID WND1-2022 (370)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NW343_RS00445 Protein ID WP_049419249.1
Coordinates 107318..108640 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NW343_RS00450 Protein ID WP_005407534.1
Coordinates 108644..108901 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW343_RS00430 (NW343_00430) 102719..104353 - 1635 WP_099470505.1 TldD/PmbA family protein -
NW343_RS00435 (NW343_00435) 104384..106015 - 1632 WP_164254858.1 TldD/PmbA family protein -
NW343_RS00440 (NW343_00440) 106703..107317 + 615 WP_012478716.1 DUF938 domain-containing protein -
NW343_RS00445 (NW343_00445) 107318..108640 - 1323 WP_049419249.1 type II toxin-antitoxin system HipA family toxin Toxin
NW343_RS00450 (NW343_00450) 108644..108901 - 258 WP_005407534.1 helix-turn-helix transcriptional regulator Antitoxin
NW343_RS00455 (NW343_00455) 109063..112749 - 3687 WP_049427202.1 indolepyruvate ferredoxin oxidoreductase family protein -
NW343_RS00460 (NW343_00460) 112921..113556 + 636 WP_005407536.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49049.98 Da        Isoelectric Point: 6.9606

>T254520 WP_049419249.1 NZ_CP102942:c108640-107318 [Stenotrophomonas maltophilia]
MGTLQVWMNGVEVALWDDVRNGSPRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVAIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAHPPEDIQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGKWCIPTGNTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFNDQRALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVRRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSNVSEPIFNGLRAAAARLSSMAPEA

Download         Length: 1323 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9584.97 Da        Isoelectric Point: 11.8468

>AT254520 WP_005407534.1 NZ_CP102942:c108901-108644 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLAPLMRAFRRQAGLSQAQLAERLGISRQAVGALERDPASASFERLMRIWAVLGLEVSLQQRSPQENT
SSLEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References