Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4929047..4930728 Replicon chromosome
Accession NZ_CP102940
Organism Klebsiella pneumoniae strain SCAID PND1-2022 (426)

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag NW340_RS24030 Protein ID WP_004146663.1
Coordinates 4929047..4929964 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag NW340_RS24035 Protein ID WP_032418188.1
Coordinates 4929970..4930728 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW340_RS24010 (4924353) 4924353..4925873 + 1521 WP_032418186.1 sugar ABC transporter ATP-binding protein -
NW340_RS24015 (4925870) 4925870..4926868 + 999 WP_002885172.1 ribose ABC transporter permease -
NW340_RS24020 (4926899) 4926899..4927840 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NW340_RS24025 (4927915) 4927915..4928922 + 1008 WP_032418187.1 carbohydrate kinase family protein -
NW340_RS24030 (4929047) 4929047..4929964 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NW340_RS24035 (4929970) 4929970..4930728 - 759 WP_032418188.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NW340_RS24040 (4930814) 4930814..4931542 - 729 WP_004210017.1 response regulator transcription factor -
NW340_RS24045 (4931815) 4931815..4933962 + 2148 WP_077598926.1 formate dehydrogenase subunit alpha -
NW340_RS24050 (4933959) 4933959..4934102 - 144 WP_022631365.1 hypothetical protein -
NW340_RS24055 (4934308) 4934308..4934994 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T254517 WP_004146663.1 NZ_CP102940:c4929964-4929047 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28620.99 Da        Isoelectric Point: 10.0001

>AT254517 WP_032418188.1 NZ_CP102940:c4930728-4929970 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2XCI1

Antitoxin

Source ID Structure

References