Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2672436..2674024 Replicon chromosome
Accession NZ_CP102940
Organism Klebsiella pneumoniae strain SCAID PND1-2022 (426)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NW340_RS13100 Protein ID WP_004184027.1
Coordinates 2672436..2673758 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NW340_RS13105 Protein ID WP_004176198.1
Coordinates 2673758..2674024 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW340_RS13085 (2667492) 2667492..2669993 + 2502 WP_258383250.1 fimbria/pilus outer membrane usher protein -
NW340_RS13090 (2669981) 2669981..2670985 + 1005 WP_016946380.1 fimbrial protein -
NW340_RS13095 (2671127) 2671127..2672419 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NW340_RS13100 (2672436) 2672436..2673758 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
NW340_RS13105 (2673758) 2673758..2674024 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NW340_RS13110 (2674290) 2674290..2674616 - 327 WP_004215084.1 hydroxyisourate hydrolase -
NW340_RS13115 (2674613) 2674613..2675113 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NW340_RS13120 (2675091) 2675091..2676470 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NW340_RS13125 (2676816) 2676816..2677970 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NW340_RS13130 (2677951) 2677951..2678874 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T254513 WP_004184027.1 NZ_CP102940:c2673758-2672436 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT254513 WP_004176198.1 NZ_CP102940:c2674024-2673758 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References