25451

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1228045..1228676 Replicon chromosome
Accession NC_015758
Organism Mycobacterium africanum GM041182

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag MAF_RS05845 Protein ID WP_003405820.1
Coordinates 1228045..1228356 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MAF_RS05850 Protein ID WP_003405836.1
Coordinates 1228356..1228676 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAF_RS05825 1223524..1224948 - 1425 WP_003405805.1 class II fumarate hydratase -
MAF_RS05830 1224979..1226067 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
MAF_RS05835 1226123..1226767 + 645 WP_003915494.1 DUF4245 domain-containing protein -
MAF_RS05840 1226774..1227933 - 1160 Protein_1140 AI-2E family transporter -
MAF_RS05845 1228045..1228356 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MAF_RS05850 1228356..1228676 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MAF_RS20845 1228686..1230211 + 1526 Protein_1143 carboxylesterase/lipase family protein -
MAF_RS05865 1230229..1231341 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MAF_RS05870 1231351..1231608 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MAF_RS05875 1231598..1232845 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MAF_RS05880 1232842..1233480 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T25451 WP_003405820.1 NC_015758:c1228356-1228045 [Mycobacterium tuberculosis variant africanum GM041182]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T25451 NC_015758:c1228356-1228045 [Mycobacterium tuberculosis variant africanum GM041182]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT25451 WP_003405836.1 NC_015758:c1228676-1228356 [Mycobacterium tuberculosis variant africanum GM041182]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT25451 NC_015758:c1228676-1228356 [Mycobacterium tuberculosis variant africanum GM041182]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References