Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 778348..779005 Replicon chromosome
Accession NZ_CP102940
Organism Klebsiella pneumoniae strain SCAID PND1-2022 (426)

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NW340_RS03855 Protein ID WP_002916310.1
Coordinates 778595..779005 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NW340_RS03850 Protein ID WP_002916312.1
Coordinates 778348..778614 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW340_RS03825 (773504) 773504..774937 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
NW340_RS03830 (775056) 775056..775784 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NW340_RS03835 (775834) 775834..776145 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NW340_RS03840 (776309) 776309..776968 + 660 WP_002916317.1 hemolysin III family protein -
NW340_RS03845 (777119) 777119..778102 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NW340_RS03850 (778348) 778348..778614 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NW340_RS03855 (778595) 778595..779005 + 411 WP_002916310.1 protein YgfX Toxin
NW340_RS03860 (779012) 779012..779533 - 522 WP_004144730.1 flavodoxin FldB -
NW340_RS03865 (779634) 779634..780530 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NW340_RS03870 (780553) 780553..781266 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NW340_RS03875 (781272) 781272..783005 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254508 WP_002916310.1 NZ_CP102940:778595-779005 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254508 WP_002916312.1 NZ_CP102940:778348-778614 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References