Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 30327..30911 Replicon plasmid unnamed1
Accession NZ_CP102935
Organism Acinetobacter sp. AOR07_HL

Toxin (Protein)


Gene name PumA Uniprot ID N9JY46
Locus tag MKL45_RS18340 Protein ID WP_000286963.1
Coordinates 30609..30911 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MKL45_RS18335 Protein ID WP_000985610.1
Coordinates 30327..30608 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKL45_RS18295 (MKL45_18300) 25560..25772 + 213 WP_016653394.1 hypothetical protein -
MKL45_RS18300 (MKL45_18305) 25897..26106 - 210 WP_000069471.1 hypothetical protein -
MKL45_RS18305 (MKL45_18310) 26099..26401 - 303 WP_001140619.1 XRE family transcriptional regulator -
MKL45_RS18310 (MKL45_18315) 26394..26750 - 357 WP_000269903.1 type II toxin-antitoxin system RelE/ParE family toxin -
MKL45_RS18315 (MKL45_18320) 27458..27994 + 537 WP_009501148.1 porin family protein -
MKL45_RS18320 (MKL45_18325) 28164..28394 - 231 WP_009501150.1 hypothetical protein -
MKL45_RS18325 (MKL45_18330) 28731..29102 + 372 WP_009501156.1 RcnB family protein -
MKL45_RS18330 (MKL45_18335) 29166..30099 - 934 Protein_36 IS5-like element ISAba13 family transposase -
MKL45_RS18335 (MKL45_18340) 30327..30608 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
MKL45_RS18340 (MKL45_18345) 30609..30911 - 303 WP_000286963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MKL45_RS18345 (MKL45_18350) 31073..31612 - 540 WP_002055813.1 hypothetical protein -
MKL45_RS18350 (MKL45_18355) 31842..33064 + 1223 Protein_40 IS256 family transposase -
MKL45_RS18355 (MKL45_18360) 33107..35773 + 2667 WP_109850699.1 excinuclease ABC subunit UvrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..133577 133577
- inside IScluster/Tn - - 24319..43036 18717


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11545.02 Da        Isoelectric Point: 4.6838

>T254504 WP_000286963.1 NZ_CP102935:c30911-30609 [Acinetobacter sp. AOR07_HL]
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT254504 WP_000985610.1 NZ_CP102935:c30608-30327 [Acinetobacter sp. AOR07_HL]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836MGN2

Antitoxin

Source ID Structure

References