Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4554024..4554640 Replicon chromosome
Accession NZ_CP102932
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NWV12_RS21710 Protein ID WP_080298642.1
Coordinates 4554024..4554395 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A808IJD0
Locus tag NWV12_RS21715 Protein ID WP_023309753.1
Coordinates 4554398..4554640 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWV12_RS21695 (NWV12_21695) 4551524..4552426 + 903 WP_008501831.1 formate dehydrogenase subunit beta -
NWV12_RS21700 (NWV12_21700) 4552423..4553058 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
NWV12_RS21705 (NWV12_21705) 4553055..4553984 + 930 WP_029741588.1 formate dehydrogenase accessory protein FdhE -
NWV12_RS21710 (NWV12_21710) 4554024..4554395 - 372 WP_080298642.1 type II toxin-antitoxin system VapC family toxin Toxin
NWV12_RS21715 (NWV12_21715) 4554398..4554640 - 243 WP_023309753.1 ribbon-helix-helix protein, CopG family Antitoxin
NWV12_RS21720 (NWV12_21720) 4554840..4555760 + 921 WP_048981029.1 alpha/beta hydrolase -
NWV12_RS21725 (NWV12_21725) 4555769..4556710 - 942 WP_039264191.1 fatty acid biosynthesis protein FabY -
NWV12_RS21730 (NWV12_21730) 4556755..4557192 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
NWV12_RS21735 (NWV12_21735) 4557189..4558070 - 882 WP_033146965.1 virulence factor BrkB family protein -
NWV12_RS21740 (NWV12_21740) 4558064..4558663 - 600 WP_039264189.1 glucose-1-phosphatase -
NWV12_RS21745 (NWV12_21745) 4558752..4559222 - 471 WP_033146967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13688.85 Da        Isoelectric Point: 6.9789

>T254498 WP_080298642.1 NZ_CP102932:c4554395-4554024 [Enterobacter sp. Crenshaw]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTATVMGVFEIIDITRDIAERSVILR
EKHGMKLPDAIILATAQSRNCPLISRNTKDFSGITGVVSPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9411.53 Da        Isoelectric Point: 4.2803

>AT254498 WP_023309753.1 NZ_CP102932:c4554640-4554398 [Enterobacter sp. Crenshaw]
ISLSADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A808IJD0

References