Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1049047..1049667 Replicon chromosome
Accession NZ_CP102932
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag NWV12_RS04895 Protein ID WP_008499287.1
Coordinates 1049047..1049265 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag NWV12_RS04900 Protein ID WP_008499288.1
Coordinates 1049293..1049667 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWV12_RS04865 (NWV12_04865) 1045060..1045320 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
NWV12_RS04870 (NWV12_04870) 1045323..1045463 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NWV12_RS04875 (NWV12_04875) 1045460..1046170 - 711 WP_048978929.1 GNAT family protein -
NWV12_RS04880 (NWV12_04880) 1046272..1047732 + 1461 WP_048978928.1 PLP-dependent aminotransferase family protein -
NWV12_RS04885 (NWV12_04885) 1047704..1048171 - 468 WP_023310598.1 YlaC family protein -
NWV12_RS04890 (NWV12_04890) 1048290..1048841 - 552 WP_023310599.1 maltose O-acetyltransferase -
NWV12_RS04895 (NWV12_04895) 1049047..1049265 - 219 WP_008499287.1 HHA domain-containing protein Toxin
NWV12_RS04900 (NWV12_04900) 1049293..1049667 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
NWV12_RS04905 (NWV12_04905) 1050179..1053325 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
NWV12_RS04910 (NWV12_04910) 1053348..1054541 - 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T254489 WP_008499287.1 NZ_CP102932:c1049265-1049047 [Enterobacter sp. Crenshaw]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT254489 WP_008499288.1 NZ_CP102932:c1049667-1049293 [Enterobacter sp. Crenshaw]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References