Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 257672..258268 Replicon chromosome
Accession NZ_CP102932
Organism Enterobacter sp. Crenshaw

Toxin (Protein)


Gene name PumA Uniprot ID A0A808I9K6
Locus tag NWV12_RS01150 Protein ID WP_048979397.1
Coordinates 257966..258268 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A808IFF3
Locus tag NWV12_RS01145 Protein ID WP_033144375.1
Coordinates 257672..257959 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWV12_RS01140 (NWV12_01140) 256044..257675 + 1632 WP_048979396.1 Na/Pi cotransporter family protein -
NWV12_RS01145 (NWV12_01145) 257672..257959 - 288 WP_033144375.1 putative addiction module antidote protein Antitoxin
NWV12_RS01150 (NWV12_01150) 257966..258268 - 303 WP_048979397.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWV12_RS01155 (NWV12_01155) 258466..259338 + 873 WP_033144377.1 23S rRNA pseudouridine(2604) synthase RluF -
NWV12_RS01160 (NWV12_01160) 259339..259611 - 273 WP_023309994.1 DUF3811 domain-containing protein -
NWV12_RS01165 (NWV12_01165) 259662..260606 - 945 WP_048979398.1 ketopantoate/pantoate/pantothenate transporter PanS -
NWV12_RS01170 (NWV12_01170) 260700..262049 - 1350 WP_023309996.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11401.17 Da        Isoelectric Point: 9.6038

>T254487 WP_048979397.1 NZ_CP102932:c258268-257966 [Enterobacter sp. Crenshaw]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRLYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10111.59 Da        Isoelectric Point: 6.4596

>AT254487 WP_033144375.1 NZ_CP102932:c257959-257672 [Enterobacter sp. Crenshaw]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808I9K6

Antitoxin

Source ID Structure
AlphaFold DB A0A808IFF3

References