Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2459926..2461665 Replicon chromosome
Accession NZ_CP102931
Organism Variovorax paradoxus strain JBCE486

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NWF24_RS11565 Protein ID WP_258354296.1
Coordinates 2459926..2460786 (+) Length 287 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NWF24_RS11570 Protein ID WP_258354297.1
Coordinates 2460829..2461665 (+) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWF24_RS11540 (NWF24_11540) 2455011..2456027 + 1017 WP_258354292.1 2-dehydropantoate 2-reductase -
NWF24_RS11545 (NWF24_11545) 2456081..2457340 + 1260 WP_258354293.1 D-amino acid dehydrogenase -
NWF24_RS11550 (NWF24_11550) 2457519..2458502 + 984 WP_258354294.1 tripartite tricarboxylate transporter substrate binding protein -
NWF24_RS11555 (NWF24_11555) 2458525..2459340 + 816 WP_258354295.1 SDR family oxidoreductase -
NWF24_RS11560 (NWF24_11560) 2459366..2459914 + 549 WP_093073561.1 cupin domain-containing protein -
NWF24_RS11565 (NWF24_11565) 2459926..2460786 + 861 WP_258354296.1 alpha/beta hydrolase Toxin
NWF24_RS11570 (NWF24_11570) 2460829..2461665 + 837 WP_258354297.1 IclR family transcriptional regulator Antitoxin
NWF24_RS11575 (NWF24_11575) 2461671..2462504 + 834 WP_258355275.1 SDR family oxidoreductase -
NWF24_RS11580 (NWF24_11580) 2462497..2464215 + 1719 WP_258354298.1 thiamine pyrophosphate-binding protein -
NWF24_RS11585 (NWF24_11585) 2464221..2465015 + 795 WP_258354299.1 aspartate dehydrogenase -
NWF24_RS11590 (NWF24_11590) 2465024..2466499 + 1476 WP_258354300.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(48-278)

Antitoxin

Transcription regulator IclR, N-terminal

(20-69)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 29627.85 Da        Isoelectric Point: 6.1140

>T254486 WP_258354296.1 NZ_CP102931:2459926-2460786 [Variovorax paradoxus]
MNDAIASDALTLPASELARLDARFPARNVAVGSGAVVSVRECGQGPVVVCLHGIGSGAASWIDTAALLASQARVIAWDAP
GYGESTPLEAAAPTAADYAARLSALLDALGIESCVLVGHSLGAITAASAARTDSRIRRLVLVSPAIGYGAPSRAETRAKV
RTERLATLDELGITGMAAKRAGRLVSDKASNHARQWVRWNMARLNDRGYRQAVELLCNADLLADLPPPMPVRVACGALDV
VTPPAACEEVARQCGVPLELVDDAGHAGYVEQPQAVAALLRESLAG

Download         Length: 861 bp

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30701.06 Da        Isoelectric Point: 5.4612

>AT254486 WP_258354297.1 NZ_CP102931:2460829-2461665 [Variovorax paradoxus]
MANNDNEAMEEGADRYNVPALERGLRVLCEFSRESRTLSAPELARRFDLPRSTVFRLLTTLENMGFLERAEGGRDYRLGL
AVLRLGFEYLASLELTQLGTPLLNRLCDELRTPCNLVVRDGRSIVYVAKVAPPTPFASSVTVGTRLPAHATVLGRILLED
LTLPQLRALYPEDKLETFSPSTPKTVNELFDMVQADRQRGYVLGEGFFESNISSIAAPVRDHSGHIVAALGATITSDHIE
ESRMDEMVLRVRGTADEISGLLNYSPARAAKVVPLRSA

Download         Length: 837 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References