Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2419300..2421022 Replicon chromosome
Accession NZ_CP102927
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name mosT Uniprot ID D0FZT9
Locus tag NW313_RS10925 Protein ID WP_000356587.1
Coordinates 2419300..2420238 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1U9VYW4
Locus tag NW313_RS10930 Protein ID WP_000095578.1
Coordinates 2420231..2421022 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW313_RS10905 2415241..2415753 - 513 WP_001166558.1 S26 family signal peptidase -
NW313_RS10910 2415737..2416084 - 348 WP_001044650.1 hypothetical protein -
NW313_RS10915 2416077..2418476 - 2400 WP_000648042.1 type IV secretion system protein TraC -
NW313_RS10920 2418476..2419168 - 693 WP_001228926.1 DsbC family protein -
NW313_RS10925 2419300..2420238 - 939 WP_000356587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NW313_RS10930 2420231..2421022 - 792 WP_000095578.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NW313_RS10935 2421243..2421629 - 387 WP_000180223.1 TraA family conjugative transfer protein -
NW313_RS10940 2421626..2422198 - 573 WP_001944091.1 type IV conjugative transfer system lipoprotein TraV -
NW313_RS10945 2422273..2423562 - 1290 WP_000647305.1 TraB/VirB10 family protein -
NW313_RS10950 2423565..2424461 - 897 WP_001911237.1 type-F conjugative transfer system secretin TraK -
NW313_RS10955 2424445..2425071 - 627 WP_000667170.1 TraE/TraK family type IV conjugative transfer system protein -
NW313_RS10960 2425068..2425349 - 282 WP_000433891.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element dfrA1 / sul2 / aph(3'')-Ib / aph(6)-Id / floR - 2332342..2478757 146415


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35548.82 Da        Isoelectric Point: 4.9081

>T254464 WP_000356587.1 NZ_CP102927:c2420238-2419300 [Vibrio cholerae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30095.47 Da        Isoelectric Point: 9.5097

>AT254464 WP_000095578.1 NZ_CP102927:c2421022-2420231 [Vibrio cholerae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VZ44

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VYW4

References