Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 52314..53224 | Replicon | plasmid pK18-45_P1 |
| Accession | NZ_CP102922 | ||
| Organism | Klebsiella quasipneumoniae strain K18-45 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | NWF33_RS25595 | Protein ID | WP_004144067.1 |
| Coordinates | 52754..53224 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6A8PHD0 |
| Locus tag | NWF33_RS25590 | Protein ID | WP_023287184.1 |
| Coordinates | 52314..52757 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWF33_RS25570 (NWF33_25570) | 47730..48479 | + | 750 | Protein_53 | IS5 family transposase | - |
| NWF33_RS25575 (NWF33_25575) | 48508..49476 | + | 969 | WP_074424072.1 | IS5 family transposase | - |
| NWF33_RS25580 (NWF33_25580) | 49672..51018 | + | 1347 | WP_225517490.1 | ThiF family adenylyltransferase | - |
| NWF33_RS25585 (NWF33_25585) | 51071..52213 | + | 1143 | Protein_56 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NWF33_RS25590 (NWF33_25590) | 52314..52757 | + | 444 | WP_023287184.1 | DUF2384 domain-containing protein | Antitoxin |
| NWF33_RS25595 (NWF33_25595) | 52754..53224 | + | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| NWF33_RS25600 (NWF33_25600) | 53311..54306 | + | 996 | WP_077254794.1 | IS5 family transposase | - |
| NWF33_RS25605 (NWF33_25605) | 54308..55276 | + | 969 | WP_074423483.1 | IS5 family transposase | - |
| NWF33_RS25610 (NWF33_25610) | 55615..56826 | - | 1212 | WP_017901247.1 | M24 family metallopeptidase | - |
| NWF33_RS25615 (NWF33_25615) | 56913..57866 | - | 954 | WP_020481021.1 | LysR substrate-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | pla | 1..220751 | 220751 | |
| - | inside | IScluster/Tn | - | - | 45586..55276 | 9690 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T254459 WP_004144067.1 NZ_CP102922:52754-53224 [Klebsiella quasipneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16522.84 Da Isoelectric Point: 10.3013
>AT254459 WP_023287184.1 NZ_CP102922:52314-52757 [Klebsiella quasipneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6A8PHD0 |