Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4629697..4630210 Replicon chromosome
Accession NZ_CP102921
Organism Klebsiella quasipneumoniae strain K18-45

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag NWF33_RS22640 Protein ID WP_017900571.1
Coordinates 4629697..4629978 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NWF33_RS22645 Protein ID WP_002886901.1
Coordinates 4629968..4630210 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWF33_RS22625 (4624739) 4624739..4626394 + 1656 WP_017900569.1 alpha,alpha-phosphotrehalase -
NWF33_RS22630 (4626780) 4626780..4628918 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
NWF33_RS22635 (4629229) 4629229..4629693 + 465 WP_004206512.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NWF33_RS22640 (4629697) 4629697..4629978 - 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWF33_RS22645 (4629968) 4629968..4630210 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NWF33_RS22650 (4630288) 4630288..4632198 - 1911 WP_017900572.1 PRD domain-containing protein -
NWF33_RS22655 (4632221) 4632221..4633372 - 1152 WP_017900573.1 lactonase family protein -
NWF33_RS22660 (4633440) 4633440..4634180 - 741 WP_017900574.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T254458 WP_017900571.1 NZ_CP102921:c4629978-4629697 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254458 WP_002886901.1 NZ_CP102921:c4630210-4629968 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References