Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 811629..812286 Replicon chromosome
Accession NZ_CP102921
Organism Klebsiella quasipneumoniae strain K18-45

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag NWF33_RS03995 Protein ID WP_004205323.1
Coordinates 811876..812286 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NWF33_RS03990 Protein ID WP_002916312.1
Coordinates 811629..811895 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWF33_RS03965 (806838) 806838..808271 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
NWF33_RS03970 (808390) 808390..809118 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
NWF33_RS03975 (809168) 809168..809479 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
NWF33_RS03980 (809642) 809642..810301 + 660 WP_004205319.1 hemolysin III family protein -
NWF33_RS03985 (810400) 810400..811383 - 984 WP_017899798.1 tRNA-modifying protein YgfZ -
NWF33_RS03990 (811629) 811629..811895 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NWF33_RS03995 (811876) 811876..812286 + 411 WP_004205323.1 protein YgfX Toxin
NWF33_RS04000 (812293) 812293..812814 - 522 WP_004205324.1 flavodoxin FldB -
NWF33_RS04005 (812915) 812915..813811 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NWF33_RS04010 (813834) 813834..814547 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NWF33_RS04015 (814553) 814553..816286 + 1734 WP_017899799.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T254450 WP_004205323.1 NZ_CP102921:811876-812286 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254450 WP_002916312.1 NZ_CP102921:811629-811895 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References