Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3161438..3162348 Replicon chromosome
Accession NZ_CP102903
Organism Klebsiella quasipneumoniae strain KW4

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag NWT71_RS15615 Protein ID WP_004144067.1
Coordinates 3161438..3161908 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NWT71_RS15620 Protein ID WP_004026357.1
Coordinates 3161905..3162348 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT71_RS15600 (3158677) 3158677..3159696 + 1020 WP_004883321.1 fimbrial protein -
NWT71_RS15605 (3160043) 3160043..3160727 + 685 Protein_3066 IS1 family transposase -
NWT71_RS15610 (3161067) 3161067..3161327 + 261 WP_004026352.1 hypothetical protein -
NWT71_RS15615 (3161438) 3161438..3161908 - 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
NWT71_RS15620 (3161905) 3161905..3162348 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NWT71_RS15625 (3162449) 3162449..3163011 - 563 Protein_3070 DUF4113 domain-containing protein -
NWT71_RS15630 (3163062) 3163062..3164330 + 1269 WP_225045528.1 hypothetical protein -
NWT71_RS15635 (3164374) 3164374..3164832 + 459 Protein_3072 integrase core domain-containing protein -
NWT71_RS15640 (3164973) 3164973..3165428 - 456 WP_192906809.1 hypothetical protein -
NWT71_RS15645 (3165540) 3165540..3166088 - 549 WP_048268732.1 3'-5' exonuclease -
NWT71_RS15650 (3166186) 3166186..3167082 - 897 WP_117252381.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3141710..3186359 44649
- inside IScluster/Tn - - 3160518..3169442 8924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T254446 WP_004144067.1 NZ_CP102903:c3161908-3161438 [Klebsiella quasipneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT254446 WP_004026357.1 NZ_CP102903:c3162348-3161905 [Klebsiella quasipneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References