Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 779367..780024 Replicon chromosome
Accession NZ_CP102903
Organism Klebsiella quasipneumoniae strain KW4

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag NWT71_RS03850 Protein ID WP_023290968.1
Coordinates 779614..780024 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NWT71_RS03845 Protein ID WP_002916312.1
Coordinates 779367..779633 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT71_RS03820 (774535) 774535..775968 - 1434 WP_065883832.1 6-phospho-beta-glucosidase -
NWT71_RS03825 (776087) 776087..776815 - 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
NWT71_RS03830 (776866) 776866..777177 + 312 WP_065883829.1 N(4)-acetylcytidine aminohydrolase -
NWT71_RS03835 (777341) 777341..778003 + 663 WP_065883827.1 hemolysin III family protein -
NWT71_RS03840 (778138) 778138..779121 - 984 WP_065883825.1 tRNA-modifying protein YgfZ -
NWT71_RS03845 (779367) 779367..779633 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NWT71_RS03850 (779614) 779614..780024 + 411 WP_023290968.1 protein YgfX Toxin
NWT71_RS03855 (780031) 780031..780552 - 522 WP_004205324.1 flavodoxin FldB -
NWT71_RS03860 (780653) 780653..781549 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NWT71_RS03865 (781572) 781572..782285 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NWT71_RS03870 (782291) 782291..784024 + 1734 WP_065883824.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T254440 WP_023290968.1 NZ_CP102903:779614-780024 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254440 WP_002916312.1 NZ_CP102903:779367-779633 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References