Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3161647..3162557 Replicon chromosome
Accession NZ_CP102898
Organism Klebsiella quasipneumoniae strain KW1

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag NWT83_RS15615 Protein ID WP_004144067.1
Coordinates 3161647..3162117 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NWT83_RS15620 Protein ID WP_004026357.1
Coordinates 3162114..3162557 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT83_RS15600 (3158886) 3158886..3159905 + 1020 WP_004883321.1 fimbrial protein -
NWT83_RS15605 (3160252) 3160252..3160936 + 685 Protein_3065 IS1 family transposase -
NWT83_RS15610 (3161276) 3161276..3161536 + 261 WP_004026352.1 hypothetical protein -
NWT83_RS15615 (3161647) 3161647..3162117 - 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
NWT83_RS15620 (3162114) 3162114..3162557 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NWT83_RS15625 (3162658) 3162658..3163220 - 563 Protein_3069 DUF4113 domain-containing protein -
NWT83_RS15630 (3163271) 3163271..3164539 + 1269 WP_225045528.1 hypothetical protein -
NWT83_RS15635 (3164583) 3164583..3165041 + 459 Protein_3071 integrase core domain-containing protein -
NWT83_RS15640 (3165182) 3165182..3165637 - 456 WP_192906809.1 hypothetical protein -
NWT83_RS15645 (3165749) 3165749..3166297 - 549 WP_048268732.1 3'-5' exonuclease -
NWT83_RS15650 (3166395) 3166395..3167291 - 897 WP_117252381.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3139421..3174975 35554
- inside IScluster/Tn - - 3160727..3171851 11124


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T254436 WP_004144067.1 NZ_CP102898:c3162117-3161647 [Klebsiella quasipneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT254436 WP_004026357.1 NZ_CP102898:c3162557-3162114 [Klebsiella quasipneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References