Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2793520..2795108 Replicon chromosome
Accession NZ_CP102898
Organism Klebsiella quasipneumoniae strain KW1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NWT83_RS13860 Protein ID WP_101995004.1
Coordinates 2793786..2795108 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2N4W0X3
Locus tag NWT83_RS13855 Protein ID WP_023289667.1
Coordinates 2793520..2793786 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT83_RS13830 (2788671) 2788671..2789594 + 924 WP_023289662.1 LysR family hpxDE operon transcriptional regulator HpxR -
NWT83_RS13835 (2789575) 2789575..2790729 - 1155 WP_023289663.1 FAD-dependent urate hydroxylase HpxO -
NWT83_RS13840 (2791075) 2791075..2792454 + 1380 WP_065882396.1 nucleobase:cation symporter-2 family protein -
NWT83_RS13845 (2792432) 2792432..2792932 + 501 WP_065882398.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NWT83_RS13850 (2792929) 2792929..2793255 + 327 WP_065882401.1 hydroxyisourate hydrolase -
NWT83_RS13855 (2793520) 2793520..2793786 + 267 WP_023289667.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NWT83_RS13860 (2793786) 2793786..2795108 + 1323 WP_101995004.1 type II toxin-antitoxin system HipA family toxin Toxin
NWT83_RS13865 (2795125) 2795125..2796417 - 1293 WP_065882402.1 glycoside hydrolase family 10 protein -
NWT83_RS13870 (2796588) 2796588..2797370 - 783 WP_065882404.1 type I methionyl aminopeptidase -
NWT83_RS13875 (2797351) 2797351..2797569 - 219 WP_002904808.1 ParD-like family protein -
NWT83_RS13880 (2797861) 2797861..2798109 - 249 WP_004205912.1 hypothetical protein -
NWT83_RS13885 (2798407) 2798407..2800062 + 1656 WP_140599567.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49197.51 Da        Isoelectric Point: 8.6110

>T254435 WP_101995004.1 NZ_CP102898:2793786-2795108 [Klebsiella quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFELLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9891.25 Da        Isoelectric Point: 7.3163

>AT254435 WP_023289667.1 NZ_CP102898:2793520-2793786 [Klebsiella quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N4W0X3

References