Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 82819..83462 Replicon plasmid pKA1-1
Accession NZ_CP102894
Organism Klebsiella quasipneumoniae strain KA1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NWT75_RS25710 Protein ID WP_048298725.1
Coordinates 82819..83235 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag NWT75_RS25715 Protein ID WP_001261275.1
Coordinates 83232..83462 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT75_RS25680 (NWT75_25680) 78287..78430 - 144 Protein_81 MbeD family mobilization/exclusion protein -
NWT75_RS25685 (NWT75_25685) 78490..78912 - 423 Protein_82 integrase core domain-containing protein -
NWT75_RS25690 (NWT75_25690) 78957..79925 + 969 WP_214184160.1 IS5-like element IS903B family transposase -
NWT75_RS25700 (NWT75_25700) 80898..81062 - 165 WP_258336605.1 hypothetical protein -
NWT75_RS25710 (NWT75_25710) 82819..83235 - 417 WP_048298725.1 type II toxin-antitoxin system VapC family toxin Toxin
NWT75_RS25715 (NWT75_25715) 83232..83462 - 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NWT75_RS25720 (NWT75_25720) 83715..86291 - 2577 WP_017901322.1 nuclease domain-containing protein -
NWT75_RS25725 (NWT75_25725) 86294..88195 - 1902 WP_258336607.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..184774 184774


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15094.58 Da        Isoelectric Point: 8.5403

>T254427 WP_048298725.1 NZ_CP102894:c83235-82819 [Klebsiella quasipneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT254427 WP_001261275.1 NZ_CP102894:c83462-83232 [Klebsiella quasipneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References