Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2597012..2598600 Replicon chromosome
Accession NZ_CP102893
Organism Klebsiella quasipneumoniae strain KA1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NWT75_RS12630 Protein ID WP_101995004.1
Coordinates 2597012..2598334 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2N4W0X3
Locus tag NWT75_RS12635 Protein ID WP_023289667.1
Coordinates 2598334..2598600 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT75_RS12605 (2592058) 2592058..2593713 - 1656 WP_064154625.1 EAL domain-containing protein -
NWT75_RS12610 (2594011) 2594011..2594259 + 249 WP_004205912.1 hypothetical protein -
NWT75_RS12615 (2594551) 2594551..2594769 + 219 WP_002904808.1 ParD-like family protein -
NWT75_RS12620 (2594750) 2594750..2595532 + 783 WP_065882404.1 type I methionyl aminopeptidase -
NWT75_RS12625 (2595703) 2595703..2596995 + 1293 WP_065882402.1 glycoside hydrolase family 10 protein -
NWT75_RS12630 (2597012) 2597012..2598334 - 1323 WP_101995004.1 type II toxin-antitoxin system HipA family toxin Toxin
NWT75_RS12635 (2598334) 2598334..2598600 - 267 WP_023289667.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NWT75_RS12640 (2598865) 2598865..2599191 - 327 WP_065882401.1 hydroxyisourate hydrolase -
NWT75_RS12645 (2599188) 2599188..2599688 - 501 WP_065882398.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NWT75_RS12650 (2599666) 2599666..2601045 - 1380 WP_065882396.1 nucleobase:cation symporter-2 family protein -
NWT75_RS12655 (2601391) 2601391..2602545 + 1155 WP_023289663.1 FAD-dependent urate hydroxylase HpxO -
NWT75_RS12660 (2602526) 2602526..2603449 - 924 WP_023289662.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49197.51 Da        Isoelectric Point: 8.6110

>T254423 WP_101995004.1 NZ_CP102893:c2598334-2597012 [Klebsiella quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFELLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9891.25 Da        Isoelectric Point: 7.3163

>AT254423 WP_023289667.1 NZ_CP102893:c2598600-2598334 [Klebsiella quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N4W0X3

References