Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1561164..1562161 Replicon chromosome
Accession NZ_CP102893
Organism Klebsiella quasipneumoniae strain KA1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NWT75_RS07630 Protein ID WP_232690963.1
Coordinates 1561607..1562161 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NWT75_RS07625 Protein ID WP_042947869.1
Coordinates 1561164..1561610 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT75_RS07610 (1557459) 1557459..1558457 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
NWT75_RS07615 (1558576) 1558576..1560096 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
NWT75_RS07620 (1560112) 1560112..1561122 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
NWT75_RS07625 (1561164) 1561164..1561610 - 447 WP_042947869.1 helix-turn-helix transcriptional regulator Antitoxin
NWT75_RS07630 (1561607) 1561607..1562161 - 555 WP_232690963.1 HipA domain-containing protein Toxin
NWT75_RS07635 (1562190) 1562190..1562711 - 522 WP_023340544.1 hypothetical protein -
NWT75_RS07640 (1562826) 1562826..1563557 - 732 WP_008804033.1 outer membrane permeability protein SanA -
NWT75_RS07645 (1563834) 1563834..1564718 - 885 WP_012967554.1 cytidine deaminase -
NWT75_RS07650 (1564847) 1564847..1565542 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
NWT75_RS07655 (1565532) 1565532..1565936 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20724.01 Da        Isoelectric Point: 5.2868

>T254417 WP_232690963.1 NZ_CP102893:c1562161-1561607 [Klebsiella quasipneumoniae]
MRLGMESVYSLLQKAPATILDYETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16410.08 Da        Isoelectric Point: 10.5417

>AT254417 WP_042947869.1 NZ_CP102893:c1561610-1561164 [Klebsiella quasipneumoniae]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRLEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References