Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4870866..4872547 Replicon chromosome
Accession NZ_CP102891
Organism Klebsiella pneumoniae strain KW3

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NWT73_RS23725 Protein ID WP_002885155.1
Coordinates 4870866..4871783 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag NWT73_RS23730 Protein ID WP_004177809.1
Coordinates 4871789..4872547 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT73_RS23705 (NWT73_23705) 4866172..4867692 + 1521 WP_040147141.1 sugar ABC transporter ATP-binding protein -
NWT73_RS23710 (NWT73_23710) 4867689..4868687 + 999 WP_002885172.1 ribose ABC transporter permease -
NWT73_RS23715 (NWT73_23715) 4868718..4869659 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NWT73_RS23720 (NWT73_23720) 4869734..4870741 + 1008 WP_080792769.1 carbohydrate kinase family protein -
NWT73_RS23725 (NWT73_23725) 4870866..4871783 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NWT73_RS23730 (NWT73_23730) 4871789..4872547 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NWT73_RS23735 (NWT73_23735) 4872633..4873361 - 729 WP_004177810.1 response regulator transcription factor -
NWT73_RS23740 (NWT73_23740) 4873634..4875781 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NWT73_RS23745 (NWT73_23745) 4876011..4876697 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T254414 WP_002885155.1 NZ_CP102891:c4871783-4870866 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT254414 WP_004177809.1 NZ_CP102891:c4872547-4871789 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References