Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4710679..4711195 Replicon chromosome
Accession NZ_CP102891
Organism Klebsiella pneumoniae strain KW3

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NWT73_RS22925 Protein ID WP_009486548.1
Coordinates 4710679..4710963 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NWT73_RS22930 Protein ID WP_002886901.1
Coordinates 4710953..4711195 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT73_RS22900 (NWT73_22900) 4706096..4706359 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NWT73_RS22905 (NWT73_22905) 4706489..4706662 + 174 WP_002886906.1 hypothetical protein -
NWT73_RS22910 (NWT73_22910) 4706665..4707408 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NWT73_RS22915 (NWT73_22915) 4707765..4709903 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NWT73_RS22920 (NWT73_22920) 4710211..4710675 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NWT73_RS22925 (NWT73_22925) 4710679..4710963 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWT73_RS22930 (NWT73_22930) 4710953..4711195 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NWT73_RS22935 (NWT73_22935) 4711273..4713183 - 1911 WP_023288161.1 PRD domain-containing protein -
NWT73_RS22940 (NWT73_22940) 4713206..4714360 - 1155 WP_002886900.1 lactonase family protein -
NWT73_RS22945 (NWT73_22945) 4714427..4715167 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T254413 WP_009486548.1 NZ_CP102891:c4710963-4710679 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254413 WP_002886901.1 NZ_CP102891:c4711195-4710953 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References