Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2643279..2644867 Replicon chromosome
Accession NZ_CP102891
Organism Klebsiella pneumoniae strain KW3

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag NWT73_RS12950 Protein ID WP_004190166.1
Coordinates 2643279..2644601 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NWT73_RS12955 Protein ID WP_002904790.1
Coordinates 2644601..2644867 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT73_RS12935 (NWT73_12935) 2638335..2640836 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
NWT73_RS12940 (NWT73_12940) 2640824..2641828 + 1005 WP_004190163.1 fimbrial protein -
NWT73_RS12945 (NWT73_12945) 2641970..2643262 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NWT73_RS12950 (NWT73_12950) 2643279..2644601 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
NWT73_RS12955 (NWT73_12955) 2644601..2644867 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NWT73_RS12960 (NWT73_12960) 2645132..2645458 - 327 WP_004143476.1 hydroxyisourate hydrolase -
NWT73_RS12965 (NWT73_12965) 2645455..2645955 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NWT73_RS12970 (NWT73_12970) 2645933..2647312 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NWT73_RS12975 (NWT73_12975) 2647658..2648812 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NWT73_RS12980 (NWT73_12980) 2648793..2649716 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T254410 WP_004190166.1 NZ_CP102891:c2644601-2643279 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254410 WP_002904790.1 NZ_CP102891:c2644867-2644601 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References